Oropharyngeal aspiration: An alternative route for challenging in a mouse model of chemical-induced asthma

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Oropharyngeal aspiration: an alternative route for challenging in a mouse model of chemical-induced asthma.

BACKGROUND To assess the importance of the route of challenge in an existing mouse model of chemical-induced asthma, we replaced intranasal instillation by oropharyngeal aspiration. To our knowledge, oropharyngeal aspiration as a challenge route has not yet been investigated in a mouse model of chemical-induced asthma. METHODS On days 1 and 8, mice were dermally sensitized with toluene diisoc...

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ژورنال

عنوان ژورنال: Toxicology

سال: 2009

ISSN: 0300-483X

DOI: 10.1016/j.tox.2009.02.007